Induction of PGRN by influenza virus inhibits the antiviral immune responses through downregulation of type I interferons signaling
Identifieur interne : 000081 ( Main/Exploration ); précédent : 000080; suivant : 000082Induction of PGRN by influenza virus inhibits the antiviral immune responses through downregulation of type I interferons signaling
Auteurs : Fanhua Wei [République populaire de Chine] ; Zhimin Jiang [République populaire de Chine] ; Honglei Sun [République populaire de Chine] ; Juan Pu [République populaire de Chine] ; Yipeng Sun [République populaire de Chine] ; Mingyang Wang [République populaire de Chine] ; Qi Tong [République populaire de Chine] ; Yuhai Bi [République populaire de Chine] ; Xiaojing Ma [République populaire de Chine, États-Unis] ; George Fu Gao [République populaire de Chine] ; Jinhua Liu [République populaire de Chine]Source :
- PLoS Pathogens [ 1553-7366 ] ; 2019.
Abstract
Type I interferons (IFNs) play a critical role in host defense against influenza virus infection, and the mechanism of influenza virus to evade type I IFNs responses remains to be fully understood. Here, we found that progranulin (PGRN) was significantly increased both
Url:
DOI: 10.1371/journal.ppat.1008062
PubMed: 31585000
PubMed Central: 6795447
Affiliations:
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Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Tong, Qi" sort="Tong, Qi" uniqKey="Tong Q" first="Qi" last="Tong">Qi Tong</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Bi, Yuhai" sort="Bi, Yuhai" uniqKey="Bi Y" first="Yuhai" last="Bi">Yuhai Bi</name><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, Institute of Microbiology, Center for Influenza Research and Early-Warning (CASCIRE), Chinese Academy of Sciences, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, Institute of Microbiology, Center for Influenza Research and Early-Warning (CASCIRE), Chinese Academy of Sciences, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Ma, Xiaojing" sort="Ma, Xiaojing" uniqKey="Ma X" first="Xiaojing" last="Ma">Xiaojing Ma</name><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>State Key Laboratory of Microbial Metabolism, Sheng Yushou Center of Cell Biology and Immunology, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Microbial Metabolism, Sheng Yushou Center of Cell Biology and Immunology, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="aff005"><addr-line>Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Gao, George Fu" sort="Gao, George Fu" uniqKey="Gao G" first="George Fu" last="Gao">George Fu Gao</name><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, Institute of Microbiology, Center for Influenza Research and Early-Warning (CASCIRE), Chinese Academy of Sciences, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, Institute of Microbiology, Center for Influenza Research and Early-Warning (CASCIRE), Chinese Academy of Sciences, 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type="wicri:Area/Main/Exploration">000081</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Induction of PGRN by influenza virus inhibits the antiviral immune responses through downregulation of type I interferons signaling</title><author><name sortKey="Wei, Fanhua" sort="Wei, Fanhua" uniqKey="Wei F" first="Fanhua" last="Wei">Fanhua Wei</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>College of Agriculture, Ningxia University, Yinchuan, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Agriculture, Ningxia University, Yinchuan</wicri:regionArea><wicri:noRegion>Yinchuan</wicri:noRegion></affiliation></author><author><name sortKey="Jiang, Zhimin" sort="Jiang, Zhimin" uniqKey="Jiang Z" first="Zhimin" last="Jiang">Zhimin Jiang</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Sun, Honglei" sort="Sun, Honglei" uniqKey="Sun H" first="Honglei" last="Sun">Honglei Sun</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Pu, Juan" sort="Pu, Juan" uniqKey="Pu J" first="Juan" last="Pu">Juan Pu</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Sun, Yipeng" sort="Sun, Yipeng" uniqKey="Sun Y" first="Yipeng" last="Sun">Yipeng Sun</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Wang, Mingyang" sort="Wang, Mingyang" uniqKey="Wang M" first="Mingyang" last="Wang">Mingyang Wang</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Tong, Qi" sort="Tong, Qi" uniqKey="Tong Q" first="Qi" last="Tong">Qi Tong</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Bi, Yuhai" sort="Bi, Yuhai" uniqKey="Bi Y" first="Yuhai" last="Bi">Yuhai Bi</name><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, Institute of Microbiology, Center for Influenza Research and Early-Warning (CASCIRE), Chinese Academy of Sciences, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, Institute of Microbiology, Center for Influenza Research and Early-Warning (CASCIRE), Chinese Academy of Sciences, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Ma, Xiaojing" sort="Ma, Xiaojing" uniqKey="Ma X" first="Xiaojing" last="Ma">Xiaojing Ma</name><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>State Key Laboratory of Microbial Metabolism, Sheng Yushou Center of Cell Biology and Immunology, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Microbial Metabolism, Sheng Yushou Center of Cell Biology and Immunology, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="aff005"><addr-line>Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Gao, George Fu" sort="Gao, George Fu" uniqKey="Gao G" first="George Fu" last="Gao">George Fu Gao</name><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, Institute of Microbiology, Center for Influenza Research and Early-Warning (CASCIRE), Chinese Academy of Sciences, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, Institute of Microbiology, Center for Influenza Research and Early-Warning (CASCIRE), Chinese Academy of Sciences, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Liu, Jinhua" sort="Liu, Jinhua" uniqKey="Liu J" first="Jinhua" last="Liu">Jinhua Liu</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author></analytic><series><title level="j">PLoS Pathogens</title><idno type="ISSN">1553-7366</idno><idno type="eISSN">1553-7374</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Type I interferons (IFNs) play a critical role in host defense against influenza virus infection, and the mechanism of influenza virus to evade type I IFNs responses remains to be fully understood. Here, we found that progranulin (PGRN) was significantly increased both <italic>in vitro</italic> and <italic>in vivo</italic> during influenza virus infection. Using a PGRN knockdown assay and PGRN-deficient mice model, we demonstrated that influenza virus-inducing PGRN negatively regulated type I IFNs production by inhibiting the activation of NF-κB and IRF3 signaling. Furthermore, we showed that PGRN directly interacted with NF-κB essential modulator (NEMO) via its Grn CDE domains. We also verified that PGRN recruited A20 to deubiquitinate K63-linked polyubiquitin chains on NEMO at K264. In addition, we found that macrophage played a major source of PGRN during influenza virus infection, and PGRN neutralizing antibodies could protect against influenza virus-induced lethality in mice. Our data identify a PGRN-mediated IFN evasion pathway exploited by influenza virus with implication in antiviral applications. These findings also provide insights into the functions and crosstalk of PGRN in innate immunity.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Kilbourne, Ed" uniqKey="Kilbourne E">ED Kilbourne</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Petrie, Jg" uniqKey="Petrie J">JG Petrie</name></author><author><name sortKey="Lauring, As" uniqKey="Lauring A">AS Lauring</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pu, J" uniqKey="Pu J">J Pu</name></author><author><name sortKey="Wang, S" uniqKey="Wang S">S Wang</name></author><author><name sortKey="Yin, Y" uniqKey="Yin Y">Y Yin</name></author><author><name sortKey="Zhang, G" uniqKey="Zhang G">G Zhang</name></author><author><name sortKey="Carter, Ra" uniqKey="Carter R">RA Carter</name></author><author><name sortKey="Wang, J" uniqKey="Wang J">J 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uniqKey="Li Y">Y Li</name></author><author><name sortKey="Yao, X" uniqKey="Yao X">X Yao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, K" uniqKey="Huang K">K Huang</name></author><author><name sortKey="Chen, A" uniqKey="Chen A">A Chen</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name></author><author><name sortKey="Song, Z" uniqKey="Song Z">Z Song</name></author><author><name sortKey="Xu, H" uniqKey="Xu H">H Xu</name></author><author><name sortKey="Cao, J" uniqKey="Cao J">J Cao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jacques, P" uniqKey="Jacques P">P Jacques</name></author><author><name sortKey="Elewaut, D" uniqKey="Elewaut D">D Elewaut</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>État de New York</li></region><settlement><li>Pékin</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Wei, Fanhua" sort="Wei, Fanhua" uniqKey="Wei F" first="Fanhua" last="Wei">Fanhua Wei</name></noRegion><name sortKey="Bi, Yuhai" sort="Bi, Yuhai" uniqKey="Bi Y" first="Yuhai" last="Bi">Yuhai Bi</name><name sortKey="Gao, George Fu" sort="Gao, George Fu" uniqKey="Gao G" first="George Fu" last="Gao">George Fu Gao</name><name sortKey="Jiang, Zhimin" sort="Jiang, Zhimin" uniqKey="Jiang Z" first="Zhimin" last="Jiang">Zhimin Jiang</name><name sortKey="Liu, Jinhua" sort="Liu, Jinhua" uniqKey="Liu J" first="Jinhua" last="Liu">Jinhua Liu</name><name sortKey="Ma, Xiaojing" sort="Ma, Xiaojing" uniqKey="Ma X" first="Xiaojing" last="Ma">Xiaojing Ma</name><name sortKey="Pu, Juan" sort="Pu, Juan" uniqKey="Pu J" first="Juan" last="Pu">Juan Pu</name><name sortKey="Sun, Honglei" sort="Sun, Honglei" uniqKey="Sun H" first="Honglei" last="Sun">Honglei Sun</name><name sortKey="Sun, Yipeng" sort="Sun, Yipeng" uniqKey="Sun Y" first="Yipeng" last="Sun">Yipeng Sun</name><name sortKey="Tong, Qi" sort="Tong, Qi" uniqKey="Tong Q" first="Qi" last="Tong">Qi Tong</name><name sortKey="Wang, Mingyang" sort="Wang, Mingyang" uniqKey="Wang M" first="Mingyang" last="Wang">Mingyang Wang</name><name sortKey="Wei, Fanhua" sort="Wei, Fanhua" uniqKey="Wei F" first="Fanhua" last="Wei">Fanhua Wei</name></country><country name="États-Unis"><region name="État de New York"><name sortKey="Ma, Xiaojing" sort="Ma, Xiaojing" uniqKey="Ma X" first="Xiaojing" last="Ma">Xiaojing Ma</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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